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A Non-Tradeskill Combine is a player-crafted combine which creates a piece of armor or an item that does not use a specific tradeskill.
These combines are usually "No Fail" and related to quests. An example of a Non-Tradeskill combine would be the Paw of Opolla Quest. In the quest you put 4 quest components (rings) into a Severed Paw to combine into your final reward, The Paw of Opolla.